Prion Science Archives: Reverse Chronological Order
Mad Cow Home ... Best Links ... Search this site

Prion Science Archives: Reverse Chronological Order

last updated: 13 Feb 99  webmaster
Reverse chronology:
...1999 ...1998
...1997 ...1996

Posted 02 Feb 1999:
Dermal prions: enough to make your skin crawl
90 cases of nvCJD predicted at end of 1998
Blood Safety and Screening Conference 21 Feb 99
Draft Factual Accounts
Risk of prion disease transmission from ocular donor tissue transplantation.
Microglial signal transduction of amyloidogenic fragments
Prophylactic potential of pentosan polysulphate in TSEs
Most Parkinson's cases sporadic
Protease-resistant prion produced in vitro lacks detectable infectivity.
Similarities between BSE and an experimental isolate of natural scrapie, CH1641.

Posted 16 Jan 1999:
Tonsil test warrants larger survery
Definition of strain type 4t
3,000 sheep survey completed (but not released)
Chicken prion tandem repeats form a stable, protease-resistant domain.
Antagonistic interactions between yeast chaperones Hsp104 and Hsp70 in prion curing.
Making (anti)sense of non-coding sequence conservation
Top scientists sign on to biology pre-print server
Bottom scientists fight new Freedom of Information Act

Posted 09 Jan 1999:
Odd prion allele found in goat
Impaired motor coordination in mice lacking prion protein.
Beyond Medline: searching full-text of many journals for CJD keywords
Am Soc Cell Biology meeting Dec. 12-16, 1998, San Francisco, CA
New web site and Latest publications at Anderson's group
14-3-3 test now offered in Belgium
Mini-review: The Yeast Psi+ Prion: Making Sense of Nonsense
Similarities between BSE and an isolate of natural scrapie, CH1641
Ubiquitinated inclusions in prion diseases

Posted 01 Jan 99:
Copper stimulates endocytosis of the prions
Copper chaperones: no known homology to prion protein
Cycling in early endosomes
Strain-dependent differences in beta-sheet conformations of rogue prion
Rapid acquisition of beta-sheet structure in the prion protein prior to multimer formation.
No prion disease in 33 UK haemophilic patients by 1995
Medical Progress: CJD and Related TSEs ... review by Gibbs
Sensitivity of the Western blot: detection of PrPres in natural sheep scrapie
New E200K cluster in Japan
Genetic factors affecting BSE and scrapie susceptibility

Posted 22 Dec 98:
Chromosomal abnormalities involving the prion gene
Experimental recommendations
References: Trisomy in chromosome 20p
References: Ring trisomy in chromosome 20p
References: Monosomy in chromosome 20p
References: Chromosome 20 genetic imprinting

Posted 15 Dec 98:
Historic duplications of the prion gene
Human-mouse prion gene synteny relationships
Prion gene syntenies in other species
References

Posted 10 Dec 98:
New Law Could Open Up Lab Books
Awarded NIH grants already in public domain, expert says
NINDS solicitation for prion experiments on primates
Jan 1999 new book: "Prions: Molecular and Cellular Biology" D Harris, ed., Horizon Press
PrP expression in B lymphocytes
Screening of sheep for BSE: further details
K200K homozygotes
Host range of CWD is altered on passage in ferrets

Posted 01 Dec 98:
Pentosan: earlier studies
Cumulative distribution anomaly in known human CJD mutations
Doxycycline control of prion protein
Prion gene sequence, neigbors, synteny, and pseudogenes
Dog prion anomaly confirmed
Can TSEs be diagnosed from urine?
Molecular screening of sheep for BSE
Structural aspects of Congo red
Phenotypic variability of GSS
The BASES Project:European research project on BSE policy-making

Posted 14 Nov 98:
Society for Neuroscience LA meeting: 10 Nov 98
Portugal meeting: 18 Nov 98
Washington DC meeting: 7-8 Dec 98
Taos NM 3-8 and 9-14th March 1999.
CJD Voice hosts meeting 13-15 June 1999
Thermodynamic stability of human prion P102L, D178N, E200K
Molecular classification of prion diseases without proteinase K
Presence of PrPc on epithelial cells of skin and mucous membranes

Posted 31 Oct 98:
Double mutants: is disease onset shorter or the same?
London to get CJD research centre
PPND and FTDP as tau repeat diseases.
Inhibiting transthyretin conformational changes
100,000 bp of human, mouse, sheep, prion genes
White-tailed deer alleles
Mystery prion peptides and alternative regulation
Phenotype-genotype studies in kuru
Phenotypic variability of GSS: new mutations D202N, GSS Q212P
Two reviews of genetic neurodegenerative diseases

Posted 22 Oct 98:
Prion gene good for something after all?
Knockouts vs knockouts: is the prion gene essential after all?
Phenotypic GSS and new mutations D202N and Q212P
Hydrogen bond donors and acceptors
Nematode genome 85% complete: no prion yet
Triplet repeat diseases: innocent inclusions?
CpG codon depletion

Posted 15 Oct 98:
Doubts raised on laminin receptor role
Prion rods contain small amounts of two host sphingolipids
Dealler suggests pentosan might halt the spread of CJD
Deaths from dementia may hide cases of new variant CJD
Genomic structure of complete bovine PrP gene
Design of peptides undergoing alpha-to-beta transition and amyloidogenesis
Molecular evolution in relation to spongiform disease
Dapsone to delay symptoms in Creutzfeldt-Jakob disease
What the dentist needs to know about TSEs

Posted 13 Oct 98:
Porphyrin inhibition of rogue prion formation
Doxycycline control of prion protein transgene expression
Collinge method to screen all sheep for BSE
Significant prion titres found outside CNS in clinically normal hamsters
Italian man and pet cat: article review
Dot blot: rapid sheep polymorphisms?
Promoter polymorphism in Alzheimer
Richard Bessen at Creighton funded by $738,000 federal grants

Posted 13 Oct 98:
Prions studied with panel of new monoclonals
FFI symposium conclusions
Prion termini in P102L GSS
What got modelled in 3D Crunch?
What did 3D Crunch do with opossum and chicken?
Genetic mechanism causing CJD insertion mutants
Yeast prion polyglutamine
Human Analogue of scrapie-responsive Gene ScRG-1

Posted 05 Oct 98:
Eight prion strains have PrPSc molecules with different conformations
Prion protein NMR structure and familial CJD
Pronghorn, fallow deer prion sequences released
Alzheimer-CJD cross-over
Repressor found in prion promoter
Other proteins with tandem repeats

Posted 23 Sep 98:
Poster sessions at Iceland meeting
Sept 28, 1998 meeting on risk analysis for BSE in the United States
Mouse IAP retrovirus
A 3' UTR mariner element is found in cow too
Appendix provides opportunity
Infectivity in blood components
The CDC plays blood politics
Unknown group patents diagnostic method
Val/val associated with loss of mental ability
Copper, GuHCl, and infectivity
New chromosomal location of prion gene
Cleaning CJD-Contaminated Instruments

Posted 21 Sep 98:
Exon 2: the mystery deepens
Is exon 2 splice-competent?
Evolution of exon 2: ancient region changes slowly
Adjacent genes
Annotated References
Supplementary material: see also on-site, off-page archive
...Exon 1: 13 sequences from 6 species with flanking regions and splice-typing
......Exon1b of cow compared to putative sheep exon 1b
......Major Cpg island around exon 1
......Motif mystery upstream of exon 1 promoter
......A long alignable region within intron 1
......Reference sequences for motif and promoter region
...Exon 2: non-redundant set for 6 species, alignment, consensus, distance table, fasta, probes, flanking regions
...Exon 3: 13 species, alignment, fasta, flanking regions, probes
......The G-21A polymorphism
......Exon 1-2-3 spliced probe sequences
...Alu and L1 retrotransposon insertion dating

Posted 01 Sep 98:
Iceland meeting of 22-27 August, 1998
Erice workshop book finally appears
Prion immunoreactivity in appendix
Prion protein expression, superoxide dismutase activity, and iNOS.
High risk sheep alleles found in New Zeeland/Australia
An unusual case of CJD: "parkinson plus"
APO E not correlated with CJD
Is beef ban followed: sensitive test for bovine mDNA
New sheep alleles
Mule Deer sequence update
N. Hunter review of scrapie

Last significant revision 27 Aug 98:
Origin of extra prion repeat units
Disentangling slippage from editing
How many different insertion mutations will eventually be found?
Predicting the final list of allowed and forbidden OPRI mutations
Insertion alleles in other species
Acknowledgements and References

Last significant revision 25 Aug 98:
Prion repeat region deletions: introduction
Distinguishing deletions
Frequency of deletion classes: worldwide summary
Slippage mechanism of deletions
Phylgeny of deletion slippage
Acknowledgements and References
Supplemental material:
...deletions in other species
...phylogeny of hairpin C
...detection of repeats with streak tool
...wildtype human reference sequence

Last significant revision 22 Aug 98:
Known point variations in human prion coding region
Predictions of new human point mutations from CpG effect
Predictions of BSE-causing mutations from CpG effect
Normal prion function: clue from adjacent genes?
Survival time of sheep with scrapie depends on prion genotype
Amino acid polymorphisms of prions in Japanese and Dutch sheep
Alignment of sheep and human prion protein
Known cow polymorphisms don't affect course of BSE

Posted 18 Aug 98:
ER and prion topology: the plot thickens
Dealler to lead blood monoclonal effort
Serious caveolin
Microdomains of GPI-anchored proteins
Diagnostics news
Mule deer on hold: AF009180, U97331, AF009181 undergoing revision
Obtaining obscure symposium proceedings
Solvent extraction as an adjunct to rendering
Mid-year nvCJD statistics
Chlamydia pneumoniae in Alzheimer glial cells

Posted 10 Jun 98:
Detection of scrapie at 4 months via tonsil biopsy
No altered aspartyl residues in scrapie
Alterations in Potassium Currents May Trigger Neurodegeneration
Number of extra repeats determines the type of cerebellar deposits
Microbiological hazards related to xenotransplantation of porcine organs into man.
CJD In Austria and Europe
Can loss-of-function prion-related diseases exist?
Extra repeat mutations in tau
New prion antibodies
E219K never occurs in sporadic CJD
Phosmet induces up-regulation of surface levels of the cellular prion protein

Posted 10 Jun 98:
Repeat region amino acid alignment: 80 species
Flanking region amino acid sequences
Hairpin C revisited in more species
Repeat sequence DNA from 76 species

Posted 02 Jun 98:
Model 10 hamster prion 90-231
3D Crunch to benefit prion research
Crunch prion sequence alignment and links
GenBank: false alarm on chromosome 7
Retrotransposon structure of the prion gene region
Longitudinal trends in the UK BSE epizootic
Beta intermediate found for 121-231
Intergen BSA and aprotonin validation study
Detection of PrpSc by multi-spectral ultraviolet fluorescence
Homology of prion globular domain to signal peptidases?
Signal peptidases are not homologous to prion protein:-- review

Posted 30 May 98:
Phylogeny for the prion protein
Revised dates of divergence
Application: the cetaceaen-artiodactyl divergence

Posted 12 May 98:
Prions: nitric oxide, superoxide, and peroxynitrite
Transport, sensory, conditioning roles for repeat region
Active site of SOD3 and regulation of NOS
Review of known copper-binding proteins (refs 1, 2)

Posted 10 May 98:
3D structure of the repeat domain: introduction
Cis and trans proline in the 3D prion structure
Evolutionary change of proline in mammalian and avian prions
The avian repeat anomaly
Blast pseudo-homologues of repeat region
So what is the structure of the repeat region?
Structure of flanking regions
Sequence variations in the repeat region
Take me to the pdb coordinates
Review of new experimental papers

Posted 07 May 98:
Bad news on BSE fed to primates
Lethal partial knockout found
Are the longer deletions diseases of normal prion function? Not proven.
Prion repeat copper by mass spec
Prion repeat binds Cu++, tryptophan, glycine carbonyl implicated
Copper binding to extra-cellular domain of Alzheimer APP
Copper chaperones in yeast
Higher repeat properties in cultured cells

Donor pool size and the risk of blood-borne CJD
TSE agents: safe working and the prevention of infection
Advice needed in Argentina 'umbanda' sheep blood CJD
Inhibiting prion conversion with central peptides, 106-141
Amyloid fibril formation by an SH3 domain.
Capillary isoelectric focusing of the scrapie prion protein

Posted 09 Apr 98:
Pullman scrapie test
Monoclonal antibody: conserved epitope on ruminant prion
Interview with researcher K.I. O'Rourke
New Scientist account
Lancet CJD epidemiology study
Belgium claims case of sporadic BSE
Collected BSE origin hypotheses
SH3 joins the amyloid club
Membrane phospholipid seeds amyloid formation

Posted 23 Apr 98:
Resistant animals could carry BSE
Table with mouse-to-hamster persistence data
TSE persistence: reservoir or replication?
Warwick meeting news 16 April 1998
Three new CJD articles in 25 Apr 98 Lancet

Posted 24 Mar 98:
Vets say maybe it was just Aujeszky's disease (pseudo-rabies)
Detwiler on differential diagnosis of Aujeszky's disease
French vache folle: more work needed -- webmaster
1920's Alzheimer's case: diagnosis confirmed
nvCJD from mononucleosis and tonsilectomies?
Husband-wife CJD
Domain-swapping and fibril formation
Reported scrapie in US: 1,117 cases (1947-1992).
Sheep ApoE alleles: no connection to scrapie
From helix to sheet after proteolysis
Contaminated lots implicated in French human growth hormone recipients
DMSO: does it dissociate amyloid fibrils?

Posted 05 Mar 98:
Chaperone review
3 new PNAS articles on prion seed capping and strain interference
Overproduction of Sup45 inhibits Sup35 seed formation
SAA fibril formations accelerated by injected seed
Strain interference in CJD
A model of prion capping in ARR sheep

Posted 13 Feb 98:
Safety tips for anatomic studies of possible CJD
Press release: Prion disease mechanism found
Highligts of the Science article
V. Lingappa offers further clarification
Commentary: prions and the endoplasmic reticulum
Why not more genetics of cattle?
Breeding out scrapie -- will it work?
MAFF answers email research queries
Are florid plaques enough?
Protective polymorphisms: codon 219 is better
Anti-prions resurrected
Chromosomal organization of 3 prion genes
Bone marrow: bad news in Blood
S100 Blood check may give simpler CJD diagnosis

Posted 03 Jan 98:
Promoter up-mutations in amyloid 'chaparone' triple Alzheimer risk
Transcriptional errors accumulate about GAGAG
nvCJD and bovine pituitary growth hormone
BSE and Prions: Uncertainties About the Agent
BSE and Prions: Uncertainties About the Article
Briefly noted: prion oligomer literature, GPI viral receptors

Posted 20 Dec 97:
Aguzzi et al.: B lymphocytes and neuroinvasion
...comentary by Paul Brown
...commentary by Gretchen Vogel
Well worth noting: selected abstracts
Leucine rich repeats: cross-beta yes, but no disease yet
Irish nvCJD concern
Similarities between inclusion-body myositis, Alzheimer, and prion disease

Posted 19 Dec 97:
Prion protein 'binds copper in vivo'
Copper binding not demonstrated: webmaster
...suitability of apo-fragment?
...missing controls
...stoichiometry inconsistencies
...so what about GPI-ceruloplasmin?
...where are those cuprione citations?
Earlier copper chelator studies: cuprizone and scrapie
Comprehensive Dec. 97 review article of copper proteins
Copper in Alzheimer's disease: histidines in APP 135-155
Repeat motifs in copper-binding membrane transporters: Menkes and Wilson disease

Posted 12 Dec 97:
Prion picture gallery
3D threaded model gallery
Prion deletion mutants

Posted 11 Dec 97:
Hamster coordinate hang-up
Structure of full-length hamster prion 29-231
Yes, we have hamster pdb coordinates!

Posted 08 Dec 97:
Yeast chaperone protein and mad cow disease
Article highlights or off-site full text 1, 2
Earlier Hsp 104 papers,
GroEL structure/function and human homologes
Is there a human psi?
Hsp 104 at Genbank, SwissProt, Blast, and Proteome
Mammalian homologues of Hsp 104
CJD-Alzheimer similarity?

Posted 28 Nov 97:
Two possible receptors found for prion protein: Lancet
Will discovery of prion receptors lead to therapy: Nature Medicine
Abstracts released 6 days after press release
Laminin binding and Alzheimer
Clue to possible strategy to block mad-cow disease: NY Times
Backgrounder on laminin receptor: webmaster
Mutations in Fanconi anemia gene similar to prion
Red deer and camel prion sequences updated
Antibodies distinguishing sheep alleles
INSERM Meeting?
Are prion deletions a CJD risk?
CJD special issue of Canada Med Assoc J

Posted 23 Nov 97:
Arginine fiasco
Copper and the prion protein
Copper: a role for prion protein?
Clusterin: an extracellular version of heat-shock protein
Are strain types a new idea?
Florid plaques unique to nvCJD?

Posted 19 Nov 97:
Prions linked to mental illness
N171S reported earlier in normal patient
N171S -- commentary
Fourth Annual Blood Safety & Screening Meeting
Sicilian goats with scrapie

Posted 08 Nov 97:
Prion-specific epitope defined by a monoclonal antibody!
Summary table: who immuno-precipitates what?
DNA/protein sequence actually used to make bovine prion
Who/what is Prionics AG?
Quick commentary on new anti-prion antibody
Imagery of possible rogue prion dimer
Accuracy of Figure 3b, 3c questioned
Aguzzi/Weissmann on prion research frontiers
Researchers closer to test for mad cow disease
New test for early diagnosis of CJD
Conformational intermediates of purified human prion

Posted 07 Nov 97 :
Images of prion fibrils and fibers
Universal architecture for amyloid diseases
N-terminal conformational change inferred
Misfolding in GSS
Hydrophobic patches at low pH

Posted 05 Nov 97:
Identification of candidate proteins binding to prion protein.
CJD stats from Germany
Parvalbumin-immunoreactive neurons associated with CJD
Increased calcium in microglia activated by prion
Astrocyte expression of prion protein
Prion research: the next frontiers
Cerebellar leucine-rich ANP interacts with ataxin-1 of SCA-1
Angiopathies masquerading as Alzheimer's disease?
Blood brain barrier in Alzheimer
Alzheimer's disease: The ins and outs of amyloid-beta
New gene linked to Alzheimer's is found
C. elegans presenilin functionally redundant with presenilin
De novo appearance of PSI+ prion in S. cerevisiae
Control of scrapie eventually possible?
Further transmission of CJD via corneal transplant.
Differential resistance to proteinase K of yeast Ure2p in vitro

Posted 31 Oct 97:
The news in brief
Best online site for CJD abstracts?
New neurodegeneration gene (HSS) maps by prion gene
Bovine prion mRNA exon 1: tissue-specific alternative splicing
New route of exposure: carotid dura mater embolization
Both prion allotypes accumulate in sporadic and Val 21O lle CJD
Protease alleles don't affect sporadic CJD
The psychiatric manifestation of CJD and mis-diagnosis

Posted 07 Oct 97:
RNA aptamers specifically interact with the prion protein
How aptamers might be used in diagnosis and therapy
Could aptamers be responsible for prion insertion mutations?
What is an apatamer anyway?
Show me a graphic of a stackable G-quartet

Posted 03 Oct 97:
Coordinate data: quality control, quality assurance
Best available mouse, hamster coordinates
A few residual issues for Official Swiss Mouse
Table of bad bonds in refined Swiss mouse
What does bond strain in prion core mean?
Amber vs Eng & Huber force fields: are structural issues real?
AMBER ... CHARMM...CHEAT95

Posted 02 Oct 97:
Liverpool group posts contradictory cat sequence
Rohwer group posts cat prion
Lots of UK dogs with TSE -- opinion
Unusual aspects of cat prion -- Alex Bossers
Cat sequences in conflict: alignment
Crocodile prion sequence predicted

Posted 02 Oct 97:
Nature nvCJD special: Jeffrey Almond, John Pattison: News and Views
Another editorial
Moira Bruce and strain-typing
Collinge gel strain-typing
Incubation periods for transmission
Collinge strain scattergraph
Smoking gun
Almond and Pattison on Human BSE
Implications for prion-only model
Highlights of Bruce strain-typing
Highlights of Collinge strain-typing

Posted 15 Sep 97:
Squalene cyclase and QW motif: relevence to prion repeat structure?
Hazardous Haplotypes in sheep
Coordinates for viewing sheep alleles threaded on mouse
Cat prion protein predicted
Predicting cow polymorphisms: bad apple bovine theory
Neurological disorder, unknown, ibex and chamois
Neuronal vacuolation in raccoons

Posted 09 Sep 97:
Sept 24 CJD in blood meeting agenda
Briefly Noted
New prion structural studies
Alleles found in rogue conformer
New prion analog found
How do prion proteins get to the brain?
Scientists pinpoint role of Alzheimer's genes
Human rabies called CJD in Montana and Washington
Harmless polymorphism?

Posted 01 Sep 97:
3D structure of longer hamster prion
Comments on hamster structure
Show me the pictures
Reference sequences -- color coded
Protein X: interaction with prion protein
Prion membrane interaction -- Warwicker
Macrophages transport prions to CNS -- Dealler
Immunodetection of rogue prion in spleens
Details on new fungal prion
Prion repeats comared to yeast S35 repeats

Posted 21 Jul 97:
Sheep-to-human and cow-to-human transmission demonstrated in vitro
New study: Isle of the Damned?
Swiss NMR group on mammalian prion structure
Prusiner: prion protein interactions with a synthetic fragment
Surprising prion binding to APP 1 and Nrf 2
Manuelidis: flogging a dead virino?

Posted 18 Jul 97:
Congo red: a universal therapy for prionic diseases?
Jump to graphic of therapy model
Anthracycline slows prion disease in Syrian hamsters
Fatal cardiac failure after a single dose of anthracycline
Congo red prolongs the incubation period in scrapie-infected hamsters

Posted 12 Jul 97:
Huntington's Disease breakthrough: quotes from the journals
Image of Congo red binding to huntingtin aggregate
Alzheimer researchers net zebrafish gene
Cause of brain cell death found for 6 diseases
Vacuolar Neuronal Degeneration In Rottweilers
Mule Deer with CWD: 3 new prion alleles reported
Kuru and nvCJD
JW Kelly on conformational disease

Posted 25 Aug 97:
New CJD mutation disrupts glycosylation: T183A
Lehmann/Harris: blockade of glycosylation promotes scrapie
Summer/Fall 1997 Meeting Abstracts
Full length prion nmr structure
Full length prion monomer easily purified in quantity from cow
Codon use in prion gene versus bovine codon use overall
New human GPI protein found
Scary news: Cross-beta filaments formed by leucine-rich repeat peptides
Clarification of cross-species in vitro barriers
Both apolipoprotein E and A-I genes
Gene affecting early onset of Alzheimer's
Squirrels: a natural reservoir for TSEs?
New jungle species: dwarf marmoset, soala ox, dwarf and giant muntjacs

Posted 12 July 97:
New plaque protein identified in brains of people with Alzheimer's disease
Alzheimer's: New Lesion Found in Diseased Brains
Alzheimer-related genetic factor linked to brain damage in boxers

Posted 10 Jul 97:
Strain back-tracking 101
Three new offline articles in The Lancet
Neuronal storage disease and CJD
Parkinson's Disease: are Lewy bodies congophilic?
Yeast prions form congophilic seed fibers
Both prion allotypes accumulates in sporadic and val 210 ile?
Alpha 1 anti-chymotrypsin polymorphisms in sporadic CJD
Formation of prion fibrils in brain slices

Posted 30 May 97:
A universal structure for congophilic amyloid?
The 15 congophilic disorders
Recruitment, species barriers, strain types, and infectivity
Congo red imagery
Details on specific amyloid proteins:
Congo red variants distinguish amyloid fibrils
Transthyretin amyloid
Model peptide transitions in vitro
Inouye on prion amyloid structure
Serum amyloid A: critical amyloid regions
Cerebral amyloid angiopathy review.
Interstitial amyloid deposits in the pituitary gland
Amyloidosis causing a progressive myopathy
Non-A beta component of Alzheimer's disease amyloid (NAC) is amyloidogenic
Conformational mimicry in Alzheimer's disease
Multiple isoforms of bovine serum amyloid-A (apoSAA)
Congophilic sporadic inclusion-body myositis and myopathy

Posted 29 May 97:
Press Release
Latest on yaest Psi fibrils
References

Posted 20 May 97:
Prion dimer interface
Application to the species barrier
Prion chameleon helices
It's not a bug, it's a feature
Quaternary structure and amyloid
X-ray Diffraction of Scrapie Prion
Interactive prion models

Posted 16 May 97:
Deadly Conformations: Protein Misfolding in Prion Disease
Models for the Conversion of PrPC to PrPSc
Conformational basis for prion strains
References

Posted 13 May 97:
What could account for a species barrier...
Phylogenetic distance?
Natural selection?
Quasi homo-oligomer interactions?
Experimental selective bias?
References

Posted 13 May 97:
In vitro formation of rogue prion
In situ formation of rogue prion
Friedreich's ataxia homologue found in yeast
Two new GPI neural proteins found
Familial CJD at codon 200
Mad Cow appeal: Researchers need brain and spinal-tap samples
1000 brain dementia study: half of CJD cases missed
Heynkes' annotated TSE citation database up to 4687
Proposal for prion disease nomenclature

Posted 10 May 97:
Introduction to kudu and oryx issues
Comparison of amino acid sequences
Comparison of nucleic acid sequences
DNA and protein sequences of kudu, oryx, sheep, and cow
References

Posted 01 May 97:
3D mouse prion coordinates finally available?
New prion mRNA complexity found
New Zealand, Australia scramble to squelch rumors
Australia's scrapie program
GSS with V129 is very different from GSS with M129
Intron sequence alleles and CJD diagnosis
No prion plaque in M232R CJD
Oryx and kudu prion sequences
Caveolin-selected peptide ligands have spaced aromatics
Amino terminus of prion inessential
Copper ion orders octapeptide repeat region
Prion dimers and the species barrier
Octapeptide insertions/deletions explained by DNA slippage
Prion gene variation in primates: correction

Posted 20 Apr 97:
Is scrapie solely a genetic disease?
High risk sheep alleles for scrapie in Scotland, US
Ovine scrapie susceptibilityin US
Sheep allele update
Prion gene neighbors

Posted 31 Mar 1997:
Bcl-2 and conserved dimerization domains
Bcl-2, apoptosis, and oxidation state
Functional domains in Bcl-2
Bcl-2 conservation of function in mammalian, avian, and viral homologs
Bax can convert Bcl-2 into activator of apoptosis
Bax heterodimerizes with Bcl-2
Bcl-2 and nitric acid protection
Review of mad goat disease
Prion gene from African wild goat
Upcoming Articles of interest in JBC
Prion gene intron alleles and diagnosis of sporadic CJD
Repeat diseases: repeat not involved in oligomerization
Neurological repeat diseases
Prion glycosylation

Posted 30 Mar 97:
Prion mRNA hairpins
AA Residues 109-121, Residues 121-231, Refolding of 121-231, AA Residues 108-218
Octapeptide Variability, Octapeptide repeats, Octapeptides in primates
Prion Evolution
Online sequence analysis
Neurotransmitters
Cu in octapeptide repeats, Copper enzymes
Anti-Prions
Prion Genetics Review
Prion Hydrophobicity
Cattle Prion DNA
Vertical Transmission
Prion Normal Role
Prion journals, Recent BSE-CJD Papers, Prion cell biology , Dealler: BSE Research
Protein 14-3-3
Heat Shock Proteins, Yeast Prions and HSP 104
Other GPI Proteins
Early drug treatments
Alzheimer's and CJD, Alzheimer and PD, Alzheimer Resources
Apo E4 and Clusterin, Two more genes for Alzheimer's disease

Posted 17 Mar 97:
How much Alzheimer is really CJD?
How good are neurologists at diagnosis anyway?
Alzheimer's very first case

Posted 5 Feb 97:
Prion creation theory myth checks out -- sort of
Griffith -- the other papers
Key 1967 paper of Alper et al.
Earliest papers of Prusiner
R.F.Marsh: collected papers

Posted 23 Dec 96:
Expanding on the Gibbs Principle
Chicken prion
Nearly-neutral mutations from primates
Prion evolution
Therapy for nvCJD
Prion dipoles and conformation
Prion helical wheels
Estimating the extent of the nvCJD epidemic

Posted 20 Dec 96:
Prion Strain Problem: overview
Encipherment and propagation of strains

Posted 17 Oct 96:
Recent journal papers
Books on BSE
Detecting BSE cattle with CSF test
Why is 14-3-3 protein found in new CJD test?
Japan researchers make mad cow breakthrough
CJD Therapy with anti-sense prion mRNA?
Prion infectious titre during incubation of Symptoms
The transgenic mouse experiment: what does it mean?
Rapid disease course in 8x prion gene over-expression
Risk of sporadic CJD with codon129 allele.
V-CJD In Ireland?
Strain typing of UK farmers with CJD
Collinge on risk to British population
Cytotoxicity of prion 106-126 unlike Alzheimer's A beta 25-35
Controversy over HSP binding to prion 180-2I study
Book Review: Lethal Legacy by Stephen Dealler
Hideyo Inouye, Boston prion researcher
Herbert Budka and research in Austria
Maternal Transmission and milk production drop as a sign of BSE
Can US researchers legally possess BSE slides?
Kuru -- What really happened?
Chronic wasting disease shows TSEs loose in US

Mad Cow Home ... Best Links ... Search this site