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Sheep allele update
Sheep allele update
Kindly provided on 10 June 1997 by:
Alex Bossers ... Web
Institute for Animal Science and Health
PO box 65, 8200 AB Lelystad, NL
Tel: +31-(0)320-238273
Fax: +31-(0)320-238153/238050
Below are DNA sequences of all different sheep
PrP-ORF allelic variants known today (wt, 112T, 136V, 137T, 141F,
154H, 171R, 171H, 211Q, and ....). They have not been posted yet to
Genbank or EMBL.
ID SHPRP_112T standard; DNA; MAM; 960 bp.
XX
DT 12-jun-1996
XX
DE Sheep prion protein (PrP) gene, complete ORF.
XX
KW cell surface molecule; prion protein.
XX
OS Ovis aries (sheep)
OC Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata;
OC Vertebrata; Eutheria; Artiodactyla; Ruminantia; Pecora; Bovoidea;
OC Bovidae; Caprinae; Ovis.
XX
CC Allelic variant of sheep PrP, M (atg) to T (acg) substitution at codon 112.
CC Note: Wildtype sequence is Q at 171 (database sequence has R at 171!)
CC ORF starts at position 72 NOT at position 36!
CC Reconstructed sequence by Alex Bossers
ctgcagactttaagtgattcttacgtgggcatttgatgctgacaccctctttattttgcagagaagtcatcatggtgaaaagccacataggcag
ttggatcctggttctctttgtggccatgtggagtgacgtgggcctctgcaagaagcgaccaaaacctggcggaggatggaacactggggggagc
cgatacccgggacagggcagtcctggaggcaaccgctatccacctcagggagggggtggctggggtcagccccatggaggtggctggggccaac
ctcatggaggtggctggggtcagccccatggtggtggctggggacagccacatggtggtggaggctggggtcaaggtggtagccacagtcagtg
gaacaagcccagtaagccaaaaaccaacacgaagcatgtggcaggagctgctgcagctggagcagtggtagggggccttggtggctacatgctg
ggaagtgccatgagcaggcctcttatacattttggcaatgactatgaggaccgttactatcgtgaaaacatgtaccgttaccccaaccaagtgt
actacagaccagtggatcagtatagtaaccagaacaactttgtgcatgactgtgtcaacatcacagtcaagcaacacacagtcaccaccaccac
caagggggagaacttcaccgaaactgacatcaagataatggagcgagtggtggagcaaatgtgcatcacccagtaccagagagaatcccaggct
tattaccaaaggggggcaagtgtgatcctcttttcttcccctcctgtgatcctcctcatctctttcctcatttttctcatagtaggataggggc
aaccttcctgttttcattatcttcttaatctttgccaggttgggggagggagtgtctacctgcagccctgtagtggtggtgtctcatttcttgc
ttctctcttgttacctgtat
5'3' Frame 3
MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSP
GGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNTKHVAG
AAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITV
KQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG
ID SHPRP_136V standard; DNA; MAM; 960 bp.
XX
DT 12-jun-1996
XX
DE Sheep prion protein (PrP) gene, complete ORF.
XX
KW cell surface molecule; prion protein.
XX
OS Ovis aries (sheep)
OC Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata;
OC Vertebrata; Eutheria; Artiodactyla; Ruminantia; Pecora; Bovoidea;
OC Bovidae; Caprinae; Ovis.
XX
CC New allelic variant of sheep PrP, A (gcc) to V (gtc) substitution at codon 136.
CC Significantly associated with high scrapie susceptibility.
CC Note: Wildtype sequence is Q at 171 (database sequence has R at 171!)
CC ORF starts at position 72 NOT at position 36!
CC Reconstructed sequence by Alex Bossers
ctgcagactttaagtgattcttacgtgggcatttgatgctgacaccctctttattttgcagagaagtcatcatggtgaaaagccacataggcag
ttggatcctggttctctttgtggccatgtggagtgacgtgggcctctgcaagaagcgaccaaaacctggcggaggatggaacactggggggagc
cgatacccgggacagggcagtcctggaggcaaccgctatccacctcagggagggggtggctggggtcagccccatggaggtggctggggccaac
ctcatggaggtggctggggtcagccccatggtggtggctggggacagccacatggtggtggaggctggggtcaaggtggtagccacagtcagtg
gaacaagcccagtaagccaaaaaccaacatgaagcatgtggcaggagctgctgcagctggagcagtggtagggggccttggtggctacatgctg
ggaagtgtcatgagcaggcctcttatacattttggcaatgactatgaggaccgttactatcgtgaaaacatgtaccgttaccccaaccaagtgt
actacagaccagtggatcagtatagtaaccagaacaactttgtgcatgactgtgtcaacatcacagtcaagcaacacacagtcaccaccaccac
caagggggagaacttcaccgaaactgacatcaagataatggagcgagtggtggagcaaatgtgcatcacccagtaccagagagaatcccaggct
tattaccaaaggggggcaagtgtgatcctcttttcttcccctcctgtgatcctcctcatctctttcctcatttttctcatagtaggataggggc
aaccttcctgttttcattatcttcttaatctttgccaggttgggggagggagtgtctacctgcagccctgtagtggtggtgtctcatttcttgc
ttctctcttgttacctgtat
5'3' Frame 3
MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSP
GGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNMKHVAG
AAAAGAVVGGLGGYMLGSVMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITV
KQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG
ID SHPRP_137T standard; DNA; MAM; 960 bp.
XX
DT 12-jun-1996
XX
DE Sheep prion protein (PrP) gene, complete ORF.
XX
KW cell surface molecule; prion protein.
XX
OS Ovis aries (sheep)
OC Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata;
OC Vertebrata; Eutheria; Artiodactyla; Ruminantia; Pecora; Bovoidea;
OC Bovidae; Caprinae; Ovis.
XX
RN [1]
RP MEDLINE; 97042305.
RA Bossers A., Schreuder B.E.C., Muileman I.H., Belt P.B.G.M., Smits M.A.;
RT "PrP genotype contributes to determining survival times of sheep with
RT natural scrapie.";
RL Journal of General Virology 77:2669-2673 (1996).
XX
CC New allelic variant of sheep PrP, M (atg) to T (acg) substitution at codon 137.
CC ORF starts at position 72 NOT at position 36!
CC Note: Wildtype sequence is Q at 171 (database sequence has R at 171!)^^
ctgcagactttaagtgattcttacgtgggcatttgatgctgacaccctctttattttgcagagaagtcatcatggtgaaaagccacataggcag
ttggatcctggttctctttgtggccatgtggagtgacgtgggcctctgcaagaagcgaccaaaacctggcggaggatggaacactggggggagc
cgatacccgggacagggcagtcctggaggcaaccgctatccacctcagggagggggtggctggggtcagccccatggaggtggctggggccaac
ctcatggaggtggctggggtcagccccatggtggtggctggggacagccacatggtggtggaggctggggtcaaggtggtagccacagtcagtg
gaacaagcccagtaagccaaaaaccaacatgaagcatgtggcaggagctgctgcagctggagcagtggtagggggccttggtggctacatgctg
ggaagtgccacgagcaggcctcttatacattttggcaatgactatgaggaccgttactatcgtgaaaacatgtaccgttaccccaaccaagtgt
actacagaccagtggatcagtatagtaaccagaacaactttgtgcatgactgtgtcaacatcacagtcaagcaacacacagtcaccaccaccac
caagggggagaacttcaccgaaactgacatcaagataatggagcgagtggtggagcaaatgtgcatcacccagtaccagagagaatcccaggct
tattaccaaaggggggcaagtgtgatcctcttttcttcccctcctgtgatcctcctcatctctttcctcatttttctcatagtaggataggggc
aaccttcctgttttcattatcttcttaatctttgccaggttgggggagggagtgtctacctgcagccctgtagtggtggtgtctcatttcttgc
ttctctcttgttacctgtat
5'3' Frame 3
MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSP
GGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNMKHVAG
AAAAGAVVGGLGGYMLGSATSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITV
KQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG
ID SHPRP_141F standard; DNA; MAM; 960 bp.
XX
DT 12-jun-1996
XX
DE Sheep prion protein (PrP) gene, complete ORF.
XX
KW cell surface molecule; prion protein.
XX
OS Ovis aries (sheep)
OC Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata;
OC Vertebrata; Eutheria; Artiodactyla; Ruminantia; Pecora; Bovoidea;
OC Bovidae; Caprinae; Ovis.
XX
RN [1]
RP MEDLINE; 97042305.
RA Bossers A., Schreuder B.E.C., Muileman I.H., Belt P.B.G.M., Smits M.A.;
RT "PrP genotype contributes to determining survival times of sheep with
RT natural scrapie.";
RL Journal of General Virology 77:2669-2673 (1996).
XX
CC New allelic variant of sheep PrP, L (ctt) to F (ttt) substitution at codon 141.
CC ORF starts at position 72 NOT at position 36!
CC Note: Wildtype sequence is Q at 171 (database sequence has R at 171!)^^
ctgcagactttaagtgattcttacgtgggcatttgatgctgacaccctctttattttgcagagaagtcatcatggtgaaaagccacataggcag
ttggatcctggttctctttgtggccatgtggagtgacgtgggcctctgcaagaagcgaccaaaacctggcggaggatggaacactggggggagc
cgatacccgggacagggcagtcctggaggcaaccgctatccacctcagggagggggtggctggggtcagccccatggaggtggctggggccaac
ctcatggaggtggctggggtcagccccatggtggtggctggggacagccacatggtggtggaggctggggtcaaggtggtagccacagtcagtg
gaacaagcccagtaagccaaaaaccaacatgaagcatgtggcaggagctgctgcagctggagcagtggtagggggccttggtggctacatgctg
ggaagtgccatgagcaggccttttatacattttggcaatgactatgaggaccgttactatcgtgaaaacatgtaccgttaccccaaccaagtgt
actacagaccagtggatcagtatagtaaccagaacaactttgtgcatgactgtgtcaacatcacagtcaagcaacacacagtcaccaccaccac
caagggggagaacttcaccgaaactgacatcaagataatggagcgagtggtggagcaaatgtgcatcacccagtaccagagagaatcccaggct
tattaccaaaggggggcaagtgtgatcctcttttcttcccctcctgtgatcctcctcatctctttcctcatttttctcatagtaggataggggc
aaccttcctgttttcattatcttcttaatctttgccaggttgggggagggagtgtctacctgcagccctgtagtggtggtgtctcatttcttgc
ttctctcttgttacctgtat
MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSP
GGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNMKHVAG
AAAAGAVVGGLGGYMLGSAMSRPFIHFGNDYEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITV
KQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG
ID SHPRP_154H standard; DNA; MAM; 960 bp.
XX
DT 12-jun-1996
XX
DE Sheep prion protein (PrP) gene, complete ORF.
XX
KW cell surface molecule; prion protein.
XX
OS Ovis aries (sheep)
OC Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata;
OC Vertebrata; Eutheria; Artiodactyla; Ruminantia; Pecora; Bovoidea;
OC Bovidae; Caprinae; Ovis.
XX
CC New allelic variant of sheep PrP, R (cgt) to H (cat) substitution at codon 154.
CC Note: Wildtype sequence is Q at 171 (database sequence has R at 171!)
CC ORF starts at position 72 NOT at position 36!
CC Reconstructed sequence by Alex Bossers
ctgcagactttaagtgattcttacgtgggcatttgatgctgacaccctctttattttgcagagaagtcatcatggtgaaaagccacataggcag
ttggatcctggttctctttgtggccatgtggagtgacgtgggcctctgcaagaagcgaccaaaacctggcggaggatggaacactggggggagc
cgatacccgggacagggcagtcctggaggcaaccgctatccacctcagggagggggtggctggggtcagccccatggaggtggctggggccaac
ctcatggaggtggctggggtcagccccatggtggtggctggggacagccacatggtggtggaggctggggtcaaggtggtagccacagtcagtg
gaacaagcccagtaagccaaaaaccaacatgaagcatgtggcaggagctgctgcagctggagcagtggtagggggccttggtggctacatgctg
ggaagtgccatgagcaggcctcttatacattttggcaatgactatgaggaccgttactatcatgaaaacatgtaccgttaccccaaccaagtgt
actacagaccagtggatcagtatagtaaccagaacaactttgtgcatgactgtgtcaacatcacagtcaagcaacacacagtcaccaccaccac
caagggggagaacttcaccgaaactgacatcaagataatggagcgagtggtggagcaaatgtgcatcacccagtaccagagagaatcccaggct
tattaccaaaggggggcaagtgtgatcctcttttcttcccctcctgtgatcctcctcatctctttcctcatttttctcatagtaggataggggc
aaccttcctgttttcattatcttcttaatctttgccaggttgggggagggagtgtctacctgcagccctgtagtggtggtgtctcatttcttgc
ttctctcttgttacctgtat
MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSP
GGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNMKHVAG
AAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYHENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITV
KQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG
ID SHPRP_171H standard; DNA; MAM; 960 bp.
XX
DT 12-jun-1996
XX
DE Sheep prion protein (PrP) gene, complete ORF.
XX
KW cell surface molecule; prion protein.
XX
OS Ovis aries (sheep)
OC Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata;
OC Vertebrata; Eutheria; Artiodactyla; Ruminantia; Pecora; Bovoidea;
OC Bovidae; Caprinae; Ovis.
XX
CC New allelic variant of sheep PrP, Q (cag) to H (cat) substitution at codon 171.
CC Note: Wildtype sequence is Q at 171 (database sequence has R at 171!)
CC ORF starts at position 72 NOT at position 36!
CC Reconstructed by Alex Bossers
ctgcagactttaagtgattcttacgtgggcatttgatgctgacaccctctttattttgcagagaagtcatcatggtgaaaagccacataggcag
ttggatcctggttctctttgtggccatgtggagtgacgtgggcctctgcaagaagcgaccaaaacctggcggaggatggaacactggggggagc
cgatacccgggacagggcagtcctggaggcaaccgctatccacctcagggagggggtggctggggtcagccccatggaggtggctggggccaac
ctcatggaggtggctggggtcagccccatggtggtggctggggacagccacatggtggtggaggctggggtcaaggtggtagccacagtcagtg
gaacaagcccagtaagccaaaaaccaacatgaagcatgtggcaggagctgctgcagctggagcagtggtagggggccttggtggctacatgctg
ggaagtgccatgagcaggcctcttatacattttggcaatgactatgaggaccgttactatcgtgaaaacatgtaccgttaccccaaccaagtgt
actacagaccagtggatcattatagtaaccagaacaactttgtgcatgactgtgtcaacatcacagtcaagcaacacacagtcaccaccaccac
caagggggagaacttcaccgaaactgacatcaagataatggagcgagtggtggagcaaatgtgcatcacccagtaccagagagaatcccaggct
tattaccaaaggggggcaagtgtgatcctcttttcttcccctcctgtgatcctcctcatctctttcctcatttttctcatagtaggataggggc
aaccttcctgttttcattatcttcttaatctttgccaggttgggggagggagtgtctacctgcagccctgtagtggtggtgtctcatttcttgc
ttctctcttgttacctgtat
MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSP
GGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNMKHVAG
AAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDHYSNQNNFVHDCVNITV
KQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG
ID SHPRP_171R standard; DNA; MAM; 960 bp.
XX
DT 12-jun-1996
XX
DE Sheep prion protein (PrP) gene, complete ORF.
XX
KW cell surface molecule; prion protein.
XX
OS Ovis aries (sheep)
OC Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata;
OC Vertebrata; Eutheria; Artiodactyla; Ruminantia; Pecora; Bovoidea;
OC Bovidae; Caprinae; Ovis.
XX
CC Allelic variant of sheep PrP, Q (cag) to R (cgg) substitution at codon 171.
CC This allelic variant is significantly associated with scrapie resistance.
CC Note: Wildtype sequence is Q at 171 (database sequence has R at 171!)
CC ORF starts at position 72 NOT at position 36!
CC Reconstructed sequence by Alex Bossers
ctgcagactttaagtgattcttacgtgggcatttgatgctgacaccctctttattttgcagagaagtcatcatggtgaaaagccacataggcag
ttggatcctggttctctttgtggccatgtggagtgacgtgggcctctgcaagaagcgaccaaaacctggcggaggatggaacactggggggagc
cgatacccgggacagggcagtcctggaggcaaccgctatccacctcagggagggggtggctggggtcagccccatggaggtggctggggccaac
ctcatggaggtggctggggtcagccccatggtggtggctggggacagccacatggtggtggaggctggggtcaaggtggtagccacagtcagtg
gaacaagcccagtaagccaaaaaccaacatgaagcatgtggcaggagctgctgcagctggagcagtggtagggggccttggtggctacatgctg
ggaagtgccatgagcaggcctcttatacattttggcaatgactatgaggaccgttactatcgtgaaaacatgtaccgttaccccaaccaagtgt
actacagaccagtggatcggtatagtaaccagaacaactttgtgcatgactgtgtcaacatcacagtcaagcaacacacagtcaccaccaccac
caagggggagaacttcaccgaaactgacatcaagataatggagcgagtggtggagcaaatgtgcatcacccagtaccagagagaatcccaggct
tattaccaaaggggggcaagtgtgatcctcttttcttcccctcctgtgatcctcctcatctctttcctcatttttctcatagtaggataggggc
aaccttcctgttttcattatcttcttaatctttgccaggttgggggagggagtgtctacctgcagccctgtagtggtggtgtctcatttcttgc
ttctctcttgttacctgtat
MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSP
GGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNMKHVAG
AAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDRYSNQNNFVHDCVNITV
KQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG
ID SHPRP_211Q standard; DNA; MAM; 960 bp.
XX
DT 12-jun-1996
XX
DE Sheep prion protein (PrP) gene, complete ORF.
XX
KW cell surface molecule; prion protein.
XX
OS Ovis aries (sheep)
OC Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata;
OC Vertebrata; Eutheria; Artiodactyla; Ruminantia; Pecora; Bovoidea;
OC Bovidae; Caprinae; Ovis.
XX
RN [1]
RP MEDLINE; 97042305.
RA Bossers A., Schreuder B.E.C., Muileman I.H., Belt P.B.G.M., Smits M.A.;
RT "PrP genotype contributes to determining survival times of sheep with
RT natural scrapie.";
RL Journal of General Virology 77:2669-2673 (1996).
XX
CC New allelic variant of sheep PrP, R (cga) to Q (caa) substitution at codon 211.
CC Note: Wildtype sequence is Q at 171 (database sequence has R at 171!)
CC ORF starts at position 72 NOT at position 36!
CC Sequence reconstruction by Alex Bossers
ctgcagactttaagtgattcttacgtgggcatttgatgctgacaccctctttattttgcagagaagtcatcatggtgaaaagccacataggcag
ttggatcctggttctctttgtggccatgtggagtgacgtgggcctctgcaagaagcgaccaaaacctggcggaggatggaacactggggggagc
cgatacccgggacagggcagtcctggaggcaaccgctatccacctcagggagggggtggctggggtcagccccatggaggtggctggggccaac
ctcatggaggtggctggggtcagccccatggtggtggctggggacagccacatggtggtggaggctggggtcaaggtggtagccacagtcagtg
gaacaagcccagtaagccaaaaaccaacatgaagcatgtggcaggagctgctgcagctggagcagtggtagggggccttggtggctacatgctg
ggaagtgccatgagcaggcctcttatacattttggcaatgactatgaggaccgttactatcgtgaaaacatgtaccgttaccccaaccaagtgt
actacagaccagtggatcagtatagtaaccagaacaactttgtgcatgactgtgtcaacatcacagtcaagcaacacacagtcaccaccaccac
caagggggagaacttcaccgaaactgacatcaagataatggagcaagtggtggagcaaatgtgcatcacccagtaccagagagaatcccaggct
tattaccaaaggggggcaagtgtgatcctcttttcttcccctcctgtgatcctcctcatctctttcctcatttttctcatagtaggataggggc
aaccttcctgttttcattatcttcttaatctttgccaggttgggggagggagtgtctacctgcagccctgtagtggtggtgtctcatttcttgc
ttctctcttgttacctgtat
MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSP
GGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNMKHVAG
AAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITV
KQHTVTTTTKGENFTETDIKIMEQVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG
ID SHPRP_wt standard; DNA; MAM; 960 bp.
XX
DT 12-jun-1996
XX
DE Sheep prion protein (PrP) gene, complete ORF.
XX
KW cell surface molecule; prion protein.
XX
OS Ovis aries (sheep)
OC Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata;
OC Vertebrata; Eutheria; Artiodactyla; Ruminantia; Pecora; Bovoidea;
OC Bovidae; Caprinae; Ovis.
XX
RN [1]
RP MEDLINE; 97042305.
RA Bossers A., Schreuder B.E.C., Muileman I.H., Belt P.B.G.M., Smits M.A.;
RT "PrP genotype contributes to determining survival times of sheep with
RT natural scrapie.";
RL Journal of General Virology 77:2669-2673 (1996).
XX
CC Note: Wildtype sequence is Q at 171 (database sequence has R at 171!)
CC ORF starts at position 72 NOT at position 36!
CC Reconstructed sequence by Alex Bossers
^^
ctgcagactttaagtgattcttacgtgggcatttgatgctgacaccctctttattttgcagagaagtcatcatggtgaaaagccacataggcag
ttggatcctggttctctttgtggccatgtggagtgacgtgggcctctgcaagaagcgaccaaaacctggcggaggatggaacactggggggagc
cgatacccgggacagggcagtcctggaggcaaccgctatccacctcagggagggggtggctggggtcagccccatggaggtggctggggccaac
ctcatggaggtggctggggtcagccccatggtggtggctggggacagccacatggtggtggaggctggggtcaaggtggtagccacagtcagtg
gaacaagcccagtaagccaaaaaccaacatgaagcatgtggcaggagctgctgcagctggagcagtggtagggggccttggtggctacatgctg
ggaagtgccatgagcaggcctcttatacattttggcaatgactatgaggaccgttactatcgtgaaaacatgtaccgttaccccaaccaagtgt
actacagaccagtggatcagtatagtaaccagaacaactttgtgcatgactgtgtcaacatcacagtcaagcaacacacagtcaccaccaccac
caagggggagaacttcaccgaaactgacatcaagataatggagcgagtggtggagcaaatgtgcatcacccagtaccagagagaatcccaggct
tattaccaaaggggggcaagtgtgatcctcttttcttcccctcctgtgatcctcctcatctctttcctcatttttctcatagtaggataggggc
aaccttcctgttttcattatcttcttaatctttgccaggttgggggagggagtgtctacctgcagccctgtagtggtggtgtctcatttcttgc
ttctctcttgttacctgtat
MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSP
GGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNMKHVAG
AAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITV
KQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG
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